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Your regular update for technical and industry information
The California Office of Environmental Health Hazard Assessment (OEHHA) has recently added1 soluble nickel compounds to the chemical list2 as known to the state to cause reproductive toxicity under the Safe Drinking Water and Toxic Enforcement Act of 1986 (commonly known as Proposition 653 ). The warning requirement of soluble nickel compounds will take effect from 26 October 2019 by following the Proposition 65 new warning regulations4 that are already in place since 30 August 2018.
The metal and several of its compounds are already listed for carcinogenicity under Proposition 65. OEHHA’s Developmental and Reproductive Toxicant Identification Committee (DARTIC) had been tasked to meet and decide whether to list nickel and its compounds under Proposition 65 or not since 2015. Recently in October, DARTIC determined at a public meeting that soluble nickel compounds were shown to cause reproductive toxicity based on the developmental and male reproductive endpoints.
Table 1. Full list of nickel and nickel compounds under Proposition 65
Chemical |
CAS No. |
Toxicological Endpoints |
Listing date |
Warning effective date |
Nickel (Metallic) |
7440-02-0 |
Cancer |
1 October 1989 |
One year after the listing |
Nickel acetate |
373-02-4 |
Cancer |
1 October 1989 |
|
Nickel carbonate |
3333-67-3 |
Cancer |
1 October 1989 |
|
Nickel carbonyl |
13463-39-3 |
Cancer Developmental |
|
|
Nickel compounds |
- |
Cancer |
7 May 2004 |
|
Nickel hydroxide |
12054-48-7; 12125-56-3
|
Cancer |
1 October 1989 |
|
Nickelocene |
1271-28-9 |
Cancer |
1 October 1989 |
|
Nickel oxide |
1313-99-1 |
Cancer |
1 October 1989 |
|
Nickel refinery dust from the pyrometallurgical process |
- |
Cancer |
1 October 1987 |
|
Nickel subsulfide |
12035-72-2 |
Cancer |
1 October 1987 |
|
Nickel (soluble compounds) |
- |
Male Reproductive Toxicity Developmental Toxicity |
26 October 2018 (NEW) |
[1] OEHHA lists soluble nickel compounds under Proposition 65
[2] Proposition 65 chemical list
[3] Proposition 65
[4] TÜV SÜD Proposition 65 Infosheet, Aug 2018
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