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USA: California adds soluble nickel compounds to Proposition 65 list

october 2018- Relevant for: electrical and electronics, softlines, hardlines, toys and children's products

The California Office of Environmental Health Hazard Assessment (OEHHA) has recently added1 soluble nickel compounds to the chemical list2 as known to the state to cause reproductive toxicity under the Safe Drinking Water and Toxic Enforcement Act of 1986 (commonly known as Proposition 653 ). The warning requirement of soluble nickel compounds will take effect from 26 October 2019 by following the Proposition 65 new warning regulations4 that are already in place since 30 August 2018.

The metal and several of its compounds are already listed for carcinogenicity under Proposition 65. OEHHA’s Developmental and Reproductive Toxicant Identification Committee (DARTIC) had been tasked to meet and decide whether to list nickel and its compounds under Proposition 65 or not since 2015. Recently in October, DARTIC determined at a public meeting that soluble nickel compounds were shown to cause reproductive toxicity based on the developmental and male reproductive endpoints.

Table 1. Full list of nickel and nickel compounds under Proposition 65


 CAS No.

 Toxicological Endpoints

 Listing date

 Warning effective date

 Nickel (Metallic)



 1 October 1989

 One year after the listing

 Nickel acetate



 1 October 1989

 Nickel carbonate



 1 October 1989

 Nickel carbonyl




  • 1 October 1987
  • 1 September 1996
  •  Nickel compounds



     7 May 2004

     Nickel hydroxide

     12054-48-7; 12125-56-3




     1 October 1989





     1 October 1989

     Nickel oxide



     1 October 1989

     Nickel refinery dust from the pyrometallurgical process



     1 October 1987

     Nickel subsulfide



     1 October 1987

     Nickel (soluble compounds)



    Male Reproductive Toxicity Developmental Toxicity


    26 October 2018


    [1] OEHHA lists soluble nickel compounds under Proposition 65

    [2] Proposition 65 chemical list

    [3] Proposition 65

    [4] TÜV SÜD Proposition 65 Infosheet, Aug 2018


    California Proposition 65

    California Proposition 65

    New warning label requirements for California Proposition 65



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